Topometric and Tomographic Indices for the Diagnosis of Keratoconus
Isaac Ramos, Fernando Faria Correia, Bernardo Lopes, Marcella Q Salomão, Rosane O Correa
Citation Information :
Ramos I, Correia FF, Lopes B, Salomão MQ, Correa RO. Topometric and Tomographic Indices for the Diagnosis of Keratoconus. Int J Kerat Ect Cor Dis 2012; 1 (2):92-99.
To compare topometric (front surface curvature) and tomographic (3D corneal shape) indices for diagnosing keratoconus.
Methods
Pentacam data from one eye randomly selected of 200 normals (N) and 177 keratoconus (KC) were analyzed. Tomographic and topometric indices were tested. Receiver operating characteristic (ROC) curves were calculated, along with pairwise comparisons.
Results
All tested variables had significant differences among N and KC (Mann-Whitney, p < 0.001). Most accurate tomographic indices had higher AUC than best topometric ones (DeLong, p < 0.05). Belin-Ambrosio D (BAD-D) had AUC of 1.00 (sensitivity 100.0%; specificity 98.5%).
Conclusion
Tomographic data was superior than topometric data to detect keratoconus. The BAD-D was an enhanced approach for detecting keratoconus.
How to cite this article
Correia FF, Ramos I, Lopes B, Salomão MQ, Luz A, Correa RO, Belin MW, Ambrósio R Jr. Topometric and Tomographic Indices for the Diagnosis of Keratoconus. Int J Kerat Ect Cor Dis 2012;1(2):92-99.
Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol 1984;28(4):293-322.
Keratoconus. Surv Ophthalmol 1998;42(4):297-319.
The ‘forme fruste’ of keratoconus. Wien Klin Wochenschr 1961;73:842-43.
Computer-assisted corneal topography. High- resolution graphic presentation and analysis of keratoscopy. Invest Ophthalmol Vis Sci 1984;25(12):1426-35.
Corneal topography of keratoconus. Cornea 1991;10(1):2-8.
Detection and classification of mild irregular astigmatism in patients with good visual acuity. Surv Ophthalmol 1998;43(1):53-58.
Computer-assisted corneal topography in keratoconus. Refract Corneal Surg 1989;5(6): 400-08.
Keratoconus detection using corneal topography. J Refract Surg 2009;25(10 Suppl):S958-62.
Automated keratoconus screening with corneal topography analysis. Invest Ophthalmol Vis Sci 1994;35(6):2749-57.
Corneal topographic and pachymetric screening of keratorefractive patients. J Refract Surg 2003;19(1):24-29.
Corneal topography in LASIK. Semin Ophthalmol 1998;13(2):64-70.
, Wilson SE. Complications of laser in situ keratomileusis: Etiology, prevention and treatment. J Refract Surg 2001;17(3):350-79.
Risk assessment for ectasia after corneal refractive surgery. Ophthalmology 2008;115(1):37-50.
Evaluation of a risk factor scoring system for corneal ectasia after LASIK in eyes with normal topography. J Refract Surg 2010;26(4):241-50.
, Belin MW. Imaging of the cornea: Topography vs tomography. J Refract Surg 2010;26(11):847-49.
New technology in corneal imaging. Int Ophthalmol Clin 2010;50(3):177-89.
Advances in anterior segment imaging and analysis. Curr Opin Ophthalmol 2009;20(4):324-32.
Epithelial, stromal, and total corneal thickness in keratoconus: Three-dimensional display with artemis very-high frequency digital ultrasound. J Refract Surg 2010;26(4):259-71.
Repeatability of layered corneal pachymetry with the artemis very high-frequency digital ultrasound arc-scanner. J Refract Surg 2010;26(9):646-59.
A reliable corneal tomography system is still needed. Ophthalmology 2003;110(3):455-56.
Corneal thickness progression from the thinnest point to the limbus: Study based on a normal and a keratoconus population to create reference values. Arquivos Brasileiros de Oftalmologia. Arquivos Brasileiros de Oftalmologia 2006;69(4):579-83.
Corneal- thickness spatial profile and corneal-volume distribution: Tomographic indices to detect keratoconus. J Cataract Refract Surg 2006;32(11):1851-59.
Novel pachymetric parameters based on corneal tomography for diagnosing keratoconus. J Refract Surg 2011;27(10):753-58.
An introduction to understanding elevation-based topography: How elevation data are displayed– a review. Clin Experiment Ophthalmol 2009;37(1):14-29.
Collaborative longitudinal evaluation of keratoconus (CLEK) study: Methods and findings to date. Cont Lens Anterior Eye 2007;30(4):223-32.
Live-epikeratophakia for keratoconus. J Cataract Refract Surg 1998;24(4):456-63.
Corneal ectasia after LASIK despite low preoperative risk: tomographic and biomechanical findings in the unoperated, stable, fellow eye. J Refract Surg 2010;26(11): 906-11.
Evaluation of corneal shape and biomechanics before LASIK. Int Ophthalmol Clin 2011;51(2):11-38.
