International Journal of Keratoconus and Ectatic Corneal Diseases

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VOLUME 6 , ISSUE 2 ( July-December, 2017 ) > List of Articles

ORIGINAL ARTICLE

To evaluate the Role and Efficacy of Collagen Cross-linkage with Ultraviolet Therapy following Riboflavin Drops with Orbscan in Cases of Progressive Keratoconus

Parmod Guleria, Vikas Sharma

Citation Information : Guleria P, Sharma V. To evaluate the Role and Efficacy of Collagen Cross-linkage with Ultraviolet Therapy following Riboflavin Drops with Orbscan in Cases of Progressive Keratoconus. Int J Kerat Ect Cor Dis 2017; 6 (2):67-72.

DOI: 10.5005/jp-journals-10025-1145

License: CC BY 3.0

Published Online: 01-12-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

To evaluate the role and efficacy of collagen cross-linkage with riboflavin (C3R) in cases of progressive keratoconus.

Study design

Prospective, nonrandomized, single-center clinical study.

Materials and methods

The C3R was done in 32 eyes of 21 patients with at least 6 months of documented progression. Outcome of the procedure was measured by means of uncorrected visual acuity (UCVA), best spectacle corrected visual acuity (BSCVA), corneal topography with Orbscan changes in posterior best fit sphere (PBFS), ratio of anterior and posterior best fit sphere (ABFS/PBFS), astigmatic changes in central 3- and 5-mm zone, central endothelial count postcorneal C3R.

Results

Thirty-two eyes with a follow-up of 6 months were analyzed. The mean age was 19.8 years. The preoperative values on the day of treatment were compared with postoperative values after the 6-month examination. The improvement in UCVA and BSCVA was statistically significant (p = 0.02 and 0.01 respectively). The change in power for PBFS was not statistically significant (p = —0.08). There was no significant difference in corneal endothelial counts pre- and post-C3R (p = 0.058). Mean value pre-C3R for ratio of ABFS/PBFS was 1.25 ± 3.7 and post-C3R was 1.22 ± 1.8 (p = 0.00). Mean value of astigmatism in 3-mm zone pre- and post-C3R was —4.3 ± 0.98 and —3.9 ± 0.66(p = 0.046) respectively. Mean value pre-C3R for astigmatism in 5-mm zone was —4.9 ± 1.91 and post-C3R was —4.0 ± 0.82 (p = 0.02).

Conclusion

The results show a stabilization and improvement in keratoconus after C3R in Indian eyes.

How to cite this article

Guleria P, Sharma V. To evaluate the Role and Efficacy of Collagen Cross-linkage with Ultraviolet Therapy following Riboflavin Drops with Orbscan in Cases of Progressive Keratoconus. Int J Kerat Ect Cor Dis 2017;6(2):67-72.


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