International Journal of Keratoconus and Ectatic Corneal Diseases

Register      Login

VOLUME 3 , ISSUE 1 ( January-April, 2014 ) > List of Articles

RESEARCH ARTICLE

Prevalence of Keratoconus among Young Arab students in Israel

Ramez Barbara, Ariela Gordon-Shaag, Michel Millodot, Einat Shneor, Maron Essa, Miriam Anton

Citation Information : Barbara R, Gordon-Shaag A, Millodot M, Shneor E, Essa M, Anton M. Prevalence of Keratoconus among Young Arab students in Israel. Int J Kerat Ect Cor Dis 2014; 3 (1):9-14.

DOI: 10.5005/jp-journals-10025-1070

Published Online: 01-04-2014

Copyright Statement:  Copyright © 2014; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Purpose

To determine the prevalence of keratoconus (KC) in an Arab population in Israel.

Materials and methods

Videokeratography was performed on volunteer students from the Academic Arab College of Education, in Haifa, Israel. All participants filled out a self-administered questionnaire to evaluate possible risk factors for KC. Univariate and multivariate analysis were performed.

Results

Data of 314 participants were analyzed and a prevalence of (N = 10), 3.18% (95% CI, 1.2 to 5.1%) was found. The only significant factor (both in univariate and multivariate analysis) that was associated with KC was parental consanguinity (OR 5.10, p = 0.02). Druzes and Bedouins had a higher prevalence than Muslims and Christians. However, the differences were not significant possibly due to the small size of the sample.

Conclusion

The result of this study was similar to other studies conducted in the Middle East, which indicate a higher prevalence of KC than in western countries. It is also recommended that people who have consanguinity in their family should be topographically tested to detect the early stages of KC.

How to cite this article

Shneor E, Millodot M, Gordon-Shaag A, Essa M, Anton M, Barbara R, Barbara A. Prevalence of Keratoconus among Young Arab Students in Israel. Int J Kerat Ect Cor Dis 2014;3(1):9-14.


PDF Share
  1. Keratoconus and related noninflammatory corneal thinning disorders. Surv-Ophthalmol 1984;28(4):293-322.
  2. Keratoconus. Surv-Ophthalmol 1998;42(4):297-319.
  3. Prognostic factors for the progression of keratoconus. Ophthalmology 1994;101(3):439-447.
  4. Keratoconus clinical findings according to different age and gender groups. Cornea 2008;27(10): 1109-1113.
  5. Comparative study of graft rejection in keratoconus patients with and without self-reported atopy. Cornea 2009;28(8):846-850.
  6. Progression of keratoconus by longitudinal assessment with corneal topography. Invest Ophthalmol Vis Sci. 2012;53(2):927-935.
  7. Prevalence and associations of keratoconus in rural Maharashtra in central India: the central India eye and medical study. Am J Ophthalmol 2009;148(5):760-765.
  8. Prevalence and associated factors of keratoconus in Jerusalem: a cross-sectional study. Ophthalmic Epidemiology 2011;18(2): 91-97.
  9. Keratoconus screening in a Lebanese students’ population. J Fr Ophtalmol 2012;35:(1):23-29.
  10. Topographic Keratoconus is not Rare in an Iranian population: the Tehran Eye Study. Ophthalmic Epidemiol 2013;20(6):385-391.
  11. Prevalence of Keratoconus in a Population-based Study in Shahroud. Cornea 2013;32(11):1441-1445.
  12. Incidence and severity of keratoconus in Asir province, Saudi Arabia. Br J Ophthalmol 2005;89(11):1403-1406.
  13. Investigation of keratoconus in an Australian refractive population. Clinical and experimental ophthalmology 2014.
  14. A keratoscopic survey of 13,395 eyes. American journal of optometry and archives of American Academy of Optometry 1959;36(1):3-11.
  15. A 48-year clinical and epidemiologic study of keratoconus. Am J Ophthalmol 1986;101(3):267-273.
  16. Clinical and epidemiological features of keratoconus genetic and external factors in the pathogenesis of the disease. Acta ophthalmologica Supplement 1986;178:1-64.
  17. Epidemiology of keratoconus in the Urals. Vestn-Oftalmol 1998;114(4):38-40.
  18. Does ethnic origin influence the incidence or severity of keratoconus? Eye (Lond) 2000;14(Pt 4):625-628.
  19. Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asians and white patients. Eye (Lond). 2004;18(4):379-383.
  20. Incidence and prevalence of keratoconus in Denmark. Acta ophthalmologica Scandinavica 2007;85(8):890-892.
  21. The cascade hypothesis of keratoconus. Cont lens Anterior Eye 2003;139-146.
  22. Prevalence of keratoconus patients in Japan. Nihon Ganka Gakkai Zasshi. 1985;89(3):407-411.
  23. Ethnic variation in central corneal refractive power and steep cornea in asians. Ophthalmic epidemiology 2014;21(2): 99-105.
  24. Is consanguinity a risk factor for keratoconus? Optom Vis Sci. 2013;90(5):448-454.
  25. Prevalence and associations of steep cornea/keratoconus in Greater Beijing. The Beijing Eye Study. PloS one 2012;7(7):e39313.
  26. A profile of keratoconus in New Zealand. Cornea 2003;22(2):122-125.
  27. Prevalence of choroidal nevi using Scanning Laser Ophthalmoscope. Ophth and Phys Optics 2014;34(1): 94-101.
  28. Characteristics of 244 patients with keratoconus seen in an optometric contact lens practice. Clinical and experimental optometry: journal of the Australian Optometrical Association 2013;96(2):219-224.
  29. Deciphering the fine-structure of tribal admixture in the Bedouin population using genomic data. Heredity (Edinb) 2014;112(2):182-189.
  30. KISA% index: a quantitative videokeratography algorithm embodying minimal topographic criteria for diagnosing keratoconus. J Cataract Refract-Surg 1999;25(10):1327-1335.
  31. The epidemiology and etiology of keratoconus. International Journal of Keratoconus and Ectatic Corneal Disease 2012;1(1):7-15.
  32. Epidemiology of keratoconus in an Iranian population. Cornea 2012;31(9):1044-1047.
  33. Consanguinity, intracommunity and intercommunity marriages in a population sample of Israeli Jews. Ann Hum Biol 2004;31(1):38-48.
  34. Consanguinity in a population sample of Israeli Muslim Arabs, Christian Arabs and Druze. 2002;4(29):422-431.
  35. Endogamy, consanguinity and community disease profiles. Community Genet 2005;8(1):17-20.
  36. Prevalence of consanguineous marriages among shi'a populations of Lebanon. J Biosoc Sci 2013;45(5):672-682.
  37. Consanguineous marriage in Iran. Ann Hum Biol 2004;31(2):263-269.
  38. Genetic counseling in southern Iran: consanguinity and reason for referral. J Genet Couns 2008;17(5):472-479.
  39. Regional variations in the prevalence of consanguinity in Saudi Arabia. Saudi Med J 2007;28(12):1881-1814.
  40. Consanguineous marriage in an urban area of Saudi Arabia: rates and adverse health effects on the offspring. Journal of community health 1998;23(1):75-83.
  41. The genetics of keratoconus. Ophthalmology clinics of North America 2003;16(4):607-620.
  42. A profile of keratoconus in New Zealand. Cornea 2003;22(2):122-125.
  43. Disease severity and family history in keratoconus. Br J Ophthalmol 2008;92(8):1108-1111.
  44. Familial keratoconus with cataract: linkage to the long arm of chromosome 15 and exclusion of candidate genes. Invest Ophthalmol Vis Sci 2003;44(12):5063-5066.
  45. Topographic evaluation of relatives of patients with keratoconus. Cornea 2008;27(8):874-878.
  46. Prevalence and associated factors of keratoconus in Jerusalem: a cross-sectional study. Ophthalmic Epidemiol 2011;18(2):91-97.
  47. The variable expression of keratoconus within monozygotic twins: dundee University Scottish Keratoconus Study (DUSKS). Cont Lens Anterior Eye 2006;29(3):123-126.
  48. Keratoconus in two pairs of identical twins. Cornea 1996;15(1):90-93.
  49. Keratoconus in 18 pairs of twins. Acta Ophthalmol 2012;90(6):482-486.
  50. The genetics of keratoconus. Clin Experiment Ophthalmol 2001;29(6):345-351.
  51. What causes keratoconus? Cornea 2012;31(6):716-719.
  52. VSX1 mutational analysis in a series of Italian patients affected by keratoconus: detection of a novel mutation. Invest Ophthalmol Vis Sci 2005;46(1):39-45.
  53. Association of polymorphisms in the hepatocyte growth factor gene promoter with keratoconus. Invest Ophthalmol Vis Sci 2011;52(11):8514-8519.
  54. Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and case-control studies. Invest Ophthalmol Vis Sci 2012;53(7):4152-4157.
  55. Localization of a gene for keratoconus to a 5.6-Mb interval on 13q32. Invest Ophthalmol Vis Sci 2009;50(4):1531-1539.
  56. Two-stage genome-wide linkage scan in keratoconus sib pair families. Invest Ophthalmol Vis Sci 2006;47(9):3791-3795.
  57. Genetic association of COL5A1 variants in keratoconus patients suggests a complex connection between corneal thinning and keratoconus. Invest Ophthalmol Vis Sci 2013;54(4):2696-2704.
  58. Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Nature genetics 2013;45(2):155-163.
  59. A genome-wide association study of central corneal thickness in Latinos. Invest Ophthalmol Vis Sci 2013; 54(4):2435-2443.
  60. Replication and meta-analysis of candidate loci identified variation at RAB3GAP1 associated with keratoconus. Invest Ophthalmol Vis Sci 2013;54(7):5132-5135.
  61. A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries. Hum-Mol-Genet 2012;21(2):421-429.
  62. Evidence for keratoconus susceptibility locus on chromosome 14: a genome-wide linkage screen using single- nucleotide polymorphism markers. Arch Ophthalmol 2010; 128(9):1191-1195.
  63. Genomewide linkage scan in a multigeneration Caucasian pedigree identifies a novel locus for keratoconus on chromosome. Genet Med 2005;7(6):397-405.
  64. A locus for autosomal dominant keratoconus: linkage to 16q22.3-q23.1 in Finnish families. Invest Ophthalmol Vis Sci 2002;43(10):3160-3164.
  65. The genetics of keratoconus: a review. Reproductive system and sexual disorders: current research 2012;(Suppl 6).
  66. Cousin marriage and premarital carrier matching in a Bedouin community in Israel: attitudes, service development and educational intervention. J Fam Plann Reprod Health Care 2004;30(1):49-51.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.