International Journal of Keratoconus and Ectatic Corneal Diseases

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VOLUME 2 , ISSUE 2 ( May-August, 2013 ) > List of Articles

RESEARCH ARTICLE

Pregnancy-induced Progression of Keratoconus in a 37-Year-Old Patient

Bruno Freitas Valbon, Juliana Glicéria, Rodrigo Teixeira Santos

Citation Information : Valbon BF, Glicéria J, Santos RT. Pregnancy-induced Progression of Keratoconus in a 37-Year-Old Patient. Int J Kerat Ect Cor Dis 2013; 2 (2):84-88.

DOI: 10.5005/jp-journals-10025-1057

Published Online: 00-08-2013

Copyright Statement:  Copyright © 2013; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Purpose

To report a case of keratoconus that progressed during pregnancy without any accompanying disease.

Methods

A case report.

Results

A patient with keratoconus that worsened during pregnancy demonstrates that pregnancy can be a previously unrecognized risk factor for progression of keratoconus.

Conclusion

To our knowledge, this is the first case reported in Brazil and the third paper in the world showing pregnancyinduced keratoconus progression in a patient with no accompanying disease.

How to cite this article

Glicéria J, Valbon BF, Santos RT, Ambrósio R Jr. Pregnancy-induced Progression of Keratoconus in a 37-Year-Old Patient. Int J Kerat Ect Cor Dis 2013;2(2):84-88.


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  1. Pregnancy-induced progression of keratoconous. Cornea 2011 Sep;30(9):991-994.
  2. Keratoconus. Surv Ophthalmol 1998;42(4):297-319.
  3. Corneal biomechanical assessment using dynamic Ultra-High-Speed Scheimpflug Technology Noncontact tonometry (UHS-ST NCT): Preliminary Results. Symposium and congress of the American Society of Cataract and Refractive Surgery. 2001. Poster. San Diego, USA.
  4. CLEK Study Group. The influence of gender and hormone status on the severity and progression of keratoconus. Cornea 2010;29:65-72.
  5. Acute keratoconus induced by hypothyroxinemia during pregnancy. J Endocrinol Invest 2008; 31:262-266.
  6. Pregnancy-related exacerbation of iatrogenic keratectasia despite corneal collagen crosslinking. J Cataract Refract Surg 2008;34:1219-1221
  7. The pregnant woman's eye. Surv Ophthalmol 1988; 32(4):219-238.
  8. Maternal corneal thickness during pregnancy. Am J Ophthalmol 1988;105(3):258-260.
  9. Expression of sex steroid hormone receptors in human cornea. Curr Eye Res 2001; 22:28-33.
  10. Expression of estrogen receptors alpha and beta, androgen receptors and progesterone receptors in human cornea. Nippon Ganka Gakkai Zasshi 2002; 106:557-564.
  11. Influence of sex on gene expression in human corneal epithelial cells. Mol Vis 2009; 15:2554-2569.
  12. Estrogen-induced changes in biomechanics in the cornea as a possible reason for keratectasia. Br J Ophthalmol 2007;91:1547-1550.
  13. Increased collagenase and gelatinase activities in keratoconus. Biochem Biophys Res Commun. 1982;107:929-936.
  14. Collagenolytic activity in keratoconus. Ann Ophthalmol 1982;14:751-754.
  15. Altered gelatinolytic activity by keratoconus corneal cells. Biochem Biophys Res Commun 1989;161:353-357.
  16. Collagenolytic proteinases in keratoconus. Cornea 2006;25:603-610.
  17. Expression of degradative enzymes and protease inhibitors in corneas with keratoconus. Invest Ophthalmol Vis Sci 1998;39:1117-1124.
  18. Increased gelatinolytic activity in keratoconus keratocyte cultures. A correlation to an altered matrix metalloproteinase-2/tissue inhibitor of metalloproteinase ratio. Cornea 1994;13:114-124.
  19. Keratoconus: Matrix metalloproteinase-2 activation and TIMP modulation. Biochim Biophys Acta 2006;1762:431-439.
  20. Tissue collagenase: serum levels during pregnancy and parturition. Eur J Obstet Gynecol Reprod Biol 1994;54:71-75.
  21. Serum collagenase levels in relation to the state of the human cervix during pregnancy and labor. Am J Obstet Gynecol. 1992;167:1284-1288.
  22. Tissue inhibitor of metalloproteinases: serum levels during pregnancy and labor, term and preterm. Obstet Gynecol 1994;83:532-537.
  23. Serum collagenase levels during pregnancy and parturition. Eur J Obstet Gynecol Reprod Biol 1994;53:55-57.
  24. Are proteinases the reason for keratoconus? Curr Eye Res 2010;35:185-191.
  25. Extracellular matrix proteases—cytokine regulation role in cancer and pregnancy. Front Biosci 2009;14:1571-1588.
  26. Relaxin modulates the ovulatory process and increases secretion of different gelatinases from granulosa and theca-interstitial cells in rats. Biol Reprod 1996;55:1276-1283.
  27. Hormonal regulation of interstitial collagenase in the uterine cervix of the pregnant guinea pig. Endocrinology 1991;128:863-871.
  28. Biochemical evidence of collagenases mediated collagenolysis as a mechanism of cervical dilatation at parturition in the guinea pig. Biol Reprod 1991; 45:764-772.
  29. Experimental relaxation of the pubic ligament of the guinea pig. Proc Soc Exp Biol Med 1926;23:661-663.
  30. Relaxin's physiological roles and other diverse actions. Endocr Rev 2004;25:205-234.
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