International Journal of Keratoconus and Ectatic Corneal Diseases

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VOLUME 1 , ISSUE 1 ( January-April, 2012 ) > List of Articles


UVA/Riboflavin Cross-Linking as an Alternative Treatment for Therapeutic Keratoplasty in Corneal Melting

MJ Tassignon, C Koppen, N Al-Sabai

Citation Information : Tassignon M, Koppen C, Al-Sabai N. UVA/Riboflavin Cross-Linking as an Alternative Treatment for Therapeutic Keratoplasty in Corneal Melting. Int J Kerat Ect Cor Dis 2012; 1 (1):61-65.

DOI: 10.5005/jp-journals-10025-1011

Published Online: 01-04-2014

Copyright Statement:  Copyright © 2012; The Author(s).



To demonstrate the effectiveness of UVA/riboflavin cross-linking (CXL) in the treatment of therapy resistant corneal melting of different etiology.


This paper describes a series of four cases presenting severe ulcerative keratitis with infectious and noninfectious causes. In spite of intensive medical treatment, corneal melting did develop in all four eyes. CXL was performed to avoid imminent corneal perforation.


After CXL, there was a rapid improvement in two eyes which healed completely within a month. In the other two eyes, an emergency keratoplasty had to be performed.


This case series highlights the effectiveness of CXL in the treatment of corneal melting as an addition to our current therapeutic armamentarium. Improvement can be expected in a few days after treatment. CXL can be considered as an adjunct therapy as soon as melting appears in severe corneal ulcers not responding to conventional, intensive treatment.

How to cite this article

Al-Sabai N, Koppen C, Tassignon MJ. UVA/Riboflavin Cross-Linking as an Alternative Treatment for Therapeutic Keratoplasty in Corneal Melting. Int J Keratoco Ectatic Corneal Dis 2012;1(1):61-65.

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  1. Results of therapeutic penetrating keratoplasty. Ophthalmology 1993;100:534-41.
  2. Cornea. Therapeutic keratoplasty 2011;2:141: 1596.
  3. Riboflavin/UVA-induced collagen cross-linking for the treatment of keratoconus. Am J Ophthalmol 2003;135:620-27.
  4. Increased resistance of cross- linking cornea against enzymatic digestion. Current Eye Research 2004;29:35-40.
  5. Bestrahlung der Hornhaut met UV-Licht und Riboflavingabe als neuer Behandlungsversuch bei Einschmelzenden Hornhautprozessen, erste Ergebnisse bei vier Patienten. Klin Monatsbl Augenheilkd 2000;217:190-93.
  6. Ultraviolet A/riboflavin corneal cross-linking for infectious keratitis associated with corneal melts. Cornea 2008;27:590-94.
  7. Riboflavin- UVA treatment in the management of edema and nonhealing ulcers of the cornea. J Refract Surg 2009;25:S803-06.
  8. Infectious keratitis treated with corneal cross-linking. Cornea 2010;29:1353-58.
  9. Corneal melts associated with topically applied nonsteroidal anti-inflammatory drugs. Tr Am Ophth Soc 2001; 99:205-12.
  10. Incidence of corneal melting in association with systemic disease in the Yorkshire region, 1995-97. Br J Ophthalmol 1999;83:941-43.
  11. Tenonplasty: A new surgical approach for the treatment of severe eye burns. Ophthalmic Surg Lasers 1997;28:105-10.
  12. Keratitis, ulceration and perforation associated with topical nonsteroidal anti- inflammatory drugs. Ophthalmology 2001;108:936-44.
  13. Necrotizing scleritis after intraocular surgery associated with the use of polyester nonabsorbable sutures. J Cataract Refract Surg 2003;29:1827-30.
  14. Antimicrobial efficacy of riboflavin/UVA combination (365 nm) in vitro for bacterial and fungal isolates: A potential new treatment for infectious keratitis. Invest Ophthalmol Vis Sci 2008;49:3402-08.
  15. In vitro antimicrobial efficacy of riboflavin and ultraviolet light on Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. J Refract Surg 2009;25: 799-802.
  16. Evaluation of antibacterial efficacy of photo-activated riboflavin using ultraviolet light (UVA). Graefes Arch Clin Exp Ophthalmol 2010;248:207-12.
  17. Escherichia coli keratitis treated with ultraviolet A/riboflavin corneal cross-linking: A case report. Eur J Ophthalmol 2009;19:295-97.
  18. Riboflavin and ultraviolet-A collagen cross-linking of the cornea for the treatment of keratitis. Cornea 2010;29:102-04.
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