International Journal of Keratoconus and Ectatic Corneal Diseases

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VOLUME 1 , ISSUE 1 ( January-April, 2012 ) > List of Articles

RESEARCH ARTICLE

Long-term Follow-up of Pachymetric and Topographic Alterations after Corneal Collagen Cross-Linking for Keratoconus

Paraskevi G Zotta, Diamantis D Almaliotis, George D Kymionis, Vasilios F Diakonis, Kostas A Moschou, Vasileios E Karampatakis

Citation Information : Zotta PG, Almaliotis DD, Kymionis GD, Diakonis VF, Moschou KA, Karampatakis VE. Long-term Follow-up of Pachymetric and Topographic Alterations after Corneal Collagen Cross-Linking for Keratoconus. Int J Kerat Ect Cor Dis 2012; 1 (1):22-25.

DOI: 10.5005/jp-journals-10025-1004

Published Online: 01-12-2013

Copyright Statement:  Copyright © 2012; The Author(s).


Abstract

Purpose

To determine the long-term alterations of corneal thickness, along with topographic outcomes, after corneal collagen cross-linking treatment (CXL) for keratoconus.

Materials and methods

In this retrospective case series, 46 patients (52 eyes), 32 males and 14 females, with progressive keratoconus were included. All eyes underwent CXL in accordance with the standard protocol (Dresden) for the treatment of their ectatic corneal disorder between January 2006 and June 2007. Pachymetric and topographic outcomes were evaluated preoperatively and at 1, 3, 6, 12, 24 and 36 months postoperatively.

Results

Mean follow-up was 28.08 ± 8.39 months (range, from 12 to 36 months). A statistically significant decline in corneal pachymetric values (at the thinnest location) when compared with preoperative values (467.65 ± 41.08 µm) was demonstrated at 1 (437.63 ± 50.57 µm), 3 (439.08 ± 52.27 µm), 6 (449.37 ± 52.73 µm), 12 (449.63 ± 83.53 µm) and 24 (459.97 ± 47.32 µm) months after CXL (p < 0.05, for all mentioned time intervals). Return to preoperative pachymetric values (469.52 ± 40.52 µm) was revealed 36 months post-CXL (p > 0.05). With respect to topographic (flat and steep keratometric values, keratoconus index), no statistically significant differences between preoperative and all postoperative intervals were found (p > 0.05, for all values for all time intervals).

Conclusion

Corneal pachymetric values reduce significantly up to 24 months after CXL treatment, while a return to preoperative values was revealed 36 months after the procedure. No significant changes’ concerning topographic outcomes was demonstrated after CXL, indicating stability of these parameters.

How to cite this article

Zotta PG, Almaliotis DD, Kymionis GD, Diakonis VF, Moschou KA, Karampatakis VE. Long-term Follow-up of Pachymetric and Topographic Alterations after Corneal Collagen Cross-Linking for Keratoconus. Int J Keratoco Ectatic Corneal Dis 2012;1(1):22-25.


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  1. A 48-year clinical and epidemiologic study of keratoconus. Am J Ophthalmol 1986;101:267-73.
  2. The genetics of keratoconus. Ophthalmol Clin North Am 2003;16:607-20.
  3. Intacs for keratoconus. Curr Opin Ophthalmol 2007;18:279-83.
  4. Extended long- term outcomes of penetrating keratoplasty for keratoconus. Ophthalmology 2006;113:1633-38.
  5. Induction of cross-links in corneal tissue. Exp Eye Res 1998;66:97-103.
  6. Biophysical principles of collagen cross-linking. Klin Monatsbl Augenheilkd 2008;225:131-37.
  7. Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet-A light. J Cataract Refract Surg 2006;32: 279-83.
  8. One-year follow-up of corneal confocal microscopy after corneal cross-linking in patients with post-laser in situ keratosmileusis ectasia and keratoconus. Am J Ophthalmol May 2009;147(5):774-78, 778.e1. Epub 5 Feb 2009.
  9. Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: Ultrastructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans. Cornea May 2007;26(4):390-97.
  10. Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: Early and late modifications. Am J Ophthalmol 2008;146:527-33.
  11. Riboflavin/ultraviolet-A induced collagen cross-linking for the treatment of keratoconus. Am J Ophthalmol 2003;135:620-27.
  12. Parasurgical therapy for keratoconus by riboflavin-ultraviolet type-A rays induced cross-linking of corneal collagen: Preliminary refractive results in an Italian study. J Cataract Refract Surg 2006;32:837-45.
  13. Riboflavin/ultraviolet-A- induced collagen cross-linking for the treatment of keratoconus. Am J Ophthalmol 2003;135:620-27.
  14. Long-term results of riboflavin ultraviolet-A corneal collagen cross-linking for keratoconus in Italy: The Siena eye cross study. Am J Ophthalmol 2010;149:585-93.
  15. Collagen cross- linking with riboflavin and ultraviolet-A light in keratoconus: Long-term results. J Cataract Refract Surg 2008;34:796-801.
  16. Corneal collagen cross-linking using riboflavin and ultraviolet- A light for keratoconus; one-year analysis using Scheimpflug imaging. J Cataract Refract Surg 2009;35:425-32.
  17. Corneal collagen cross-linking outcomes: Review. Open Ophthalmol J 11 Feb 2011;5:19-20.
  18. Corneal collagen cross-linking using riboflavin and ultraviolet-A irradiation: A review of clinical and experimental studies. Int Ophthalmol 17 Aug 2011. [Epub ahead of print]
  19. Collagen cross-linking with ribovlavin and ultraviolet-A light in keratoconus: One-year results. Oman Journal of Ophthalmology 2009;2(1):33-38.
  20. Intraocular pressure measurements after corneal collagen cross-linking with riboflavin and ultraviolet- A in eyes with keratoconus. J Cataract Refract Surg 2010;36:1724-27.
  21. Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus. Arch Ophthalmology 2009;127(10):1258-65.
  22. Refractive, topographic, tomographic, and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking. Ophthalmology 2009;116:369-78.
  23. Flattening of the cornea after collagen cross-linking for keratoconus. J Cataract Refract Surg 2011;37:1488-92.
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